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Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemicera

《工程管理前沿(英文)》   页码 82-95 doi: 10.1007/s42524-022-0233-1

摘要: During the COVID-19 pandemic, the current operating environment of pharmaceutical supply chain (PSC) has rapidly changed and faced increasing risks of disruption. The Internet of Things (IoT) and blockchain not only help enhance the efficiency of PSC operations in the information technology domain but also address complex related issues and improve the visibility, flexibility, and transparency of these operations. Although IoT and blockchain have been widely examined in the areas of supply chain and logistics management, further work on PSC is expected by the public to enhance its resilience. To respond to this call, this paper combines a literature review with semi-structured interviews to investigate the characteristics of PSC, the key aspects affecting PSC, and the challenges faced by PSC in the post-pandemic era. An IoT–blockchain-integrated hospital-side oriented PSC management model is also developed. This paper highlights how IoT and blockchain technology can enhance supply chain resilience and provides a reference on how PSC members can cope with the associated risks.

关键词: pharmaceutical supply chain     Internet of Things     blockchain     resilience     post-pandemic era    

Special issue: Advancing supply chain resilience for excellence in the post-pandemic era

《工程管理前沿(英文)》 2023年 第10卷 第1期   页码 1-4 doi: 10.1007/s42524-022-0246-9

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Digital twin for healthy indoor environment: A vision for the post-pandemic era

《工程管理前沿(英文)》 2023年 第10卷 第2期   页码 300-318 doi: 10.1007/s42524-022-0244-y

摘要: Indoor environment has significant impacts on human health as people spend 90% of their time indoors. The COVID-19 pandemic and the increased public health awareness have further elevated the urgency for cultivating and maintaining a healthy indoor environment. The advancement in emerging digital twin technologies including building information modeling (BIM), Internet of Things (IoT), data analytics, and smart control have led to new opportunities for building design and operation. Despite the numerous studies on developing methods for creating digital twins and enabling new functionalities and services in smart building management, very few have focused on the health of indoor environment. There is a critical need for understanding and envisaging how digital twin paradigms can be geared towards healthy indoor environment. Therefore, this study reviews the techniques for developing digital twins and discusses how the techniques can be customized to contribute to public health. Specifically, the current applications of BIM, IoT sensing, data analytics, and smart building control technologies for building digital twins are reviewed, and the knowledge gaps and limitations are discussed to guide future research for improving environmental and occupant health. Moreover, this paper elaborates a vision for future research on integrated digital twins for a healthy indoor environment with special considerations of the above four emerging techniques and issues. This review contributes to the body of knowledge by advocating for the consideration of health in digital twin modeling and smart building services and presenting the research roadmap for digital twin-enabled healthy indoor environment.

关键词: digital twin     healthy indoor environment     building information modeling     occupant–building interaction     COVID-19    

Advancing food supply chain resilience in the post-pandemic era

《工程管理前沿(英文)》   页码 107-120 doi: 10.1007/s42524-022-0232-2

摘要: In the post-pandemic era, food supply chains and firms therein are facing unprecedented severe challenges, because once infection is detected, numerous products must be recalled or abandoned, and both suppliers and retailers in the supply chain suffer enormous loss. To survive under the pandemic, retailers have adopted different sourcing strategies, such as contingent sourcing, which, in turn, affect the upstream suppliers and hence the resilience of the whole supply chain. With the rapid development of digital technologies, retailers nowadays can utilize blockchain as a reliable and efficient way to reduce product risk and hence advance the resilience of food supply chains by improving product traceability and inspection accuracy, and making sourcing transparent. In this paper, we develop a game-theoretic model to investigate the interrelation between the retailer’s decisions on blockchain adoption and sourcing strategies. We consider that a retailer originally orders from a risky supplier while conducting an imperfect inspection to detect infected products before selling. The retailer may speculatively keep on ordering from the risky supplier or adopt contingent sourcing by ordering from an alternative safe supplier. The retailer also has an option to implement blockchain to improve the inspection accuracy and product traceability. We derive the optimal retail prices under different sourcing strategies with and without blockchain adoption and then analyze the incentives for sourcing strategy and blockchain adoption. Then, we identify the conditions of an all-win situation for food retailer, supplier, supply chain resilience, and consumers with/without government subsidy. Finally, we extend to consider the situation that some consumers have health-safety concerns and preferences for blockchain adoption.

关键词: food supply chain     blockchain     contingent sourcing     supply chain resilience    

关于后摩尔时代我国集成电路制造领域的一些思考

吴汉明, 郑飞君

《工程(英文)》 2023年 第23卷 第4期   页码 33-39 doi: 10.1016/j.eng.2022.07.021

CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS

《农业科学与工程前沿(英文)》 2022年 第9卷 第1期   页码 1-3 doi: 10.15302/J-FASE-2021431

摘要:

China is the largest agricultural producer in the world. Reducing yield losses caused by pests is an important issue and major challenge for China, especially when confronting global climate change, biological invasions and declining agricultural biodiversity of recent decades. Wang et al. (this issue) summarized the impacts of changing climate on two staple crops in China, wheat and rice (https://doi.org/FASE-2021432). They reviewed the impacts of climate change on crops, crop pests and crop diseases. Basically, increased temperature would reduce crop yields and increase pest damage. Biological invasions have become a serious threat to the agriculture worldwide. Developing approaches for monitoring and controlling invasive pests, such as fall armyworm, has been recognized as high priority for China. The excessive use of highly toxic pesticides has caused considerable damage to the environment and biodiversity, which is also one of the many contributors to the increasing outbreaks of pests and diseases. In addition, understanding interaction between crop pests and plant diseases is another critical challenge for agriculture. About 80% plant viruses can be transmitted by crop pest vectors such as aphids, whiteflies and other hemipteran pests. Therefore, to solve the problem of crop pests and diseases, suitable green crop protection methods have been identified as a key components of sustainable development. This special issue of Frontiers of Agricultural Science and Engineering outlines potential conservation and utilization of green options for crop protection.

To prevent outbreaks of crop pests, an advanced monitoring and early warning system could be the first step in crop protection. The use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. Wu et al. (this issue) summarized the fundamental information on pest monitoring and early warning in China by documenting the history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially cross border pests such as fall armyworm and locust, by international cooperation across pest-impacted countries (https://doi.org/10.15302/J-FASE-2021411). They provide an overview of long-term Chinese efforts in the fight against major pests and to present the country’s experience in crop pest monitoring and early warning technology to the world.

Field management is a traditional conservation agriculture technique on plant protection such as no-till cropping, crop rotation, intercropping and cover cropping. Shi et al. (this issue) found that soil solarization is an environmental-friendly promising strategy that achieved complete mortality to the larvae of Bradysia cellarum (https://doi.org/10.15302/J-FASE-2021402). Crop rotation, intercropping and cover cropping of different crops or plants could help to reduce the outbreak of crop pests and diseases. Wang et al. (this issue) summarized the interactions and trade-offs between plants and entomophagous arthropods, and discussed a landscape management method by sowing flowering plants in agricultural fields (https://doi.org/10.15302/J-FASE-2021427). However, such methods are limited when crop pests have already become well established in crop fields.

Pesticides are widely used in the crop protection. The ideal pesticide should have high effectiveness in the control crop pests but low toxicity to non-target organisms. In this case, biopesticides including biochemical pesticides, microbial pesticides and plant-incorporated protectants are considered to be potential ideal pesticides for crop protection. Biochemical pesticides are the naturally occurring substances, they are derived from animals, plants and microorganisms. Microbial pesticides mainly rely on bacteria, fungi, virus or protozoans as the active agent. They are environment-friendly biopesticides with high effectiveness and species-specificity, and have been commercialized worldwide, for example, Bacillus thuringiensis. Plant-incorporated protectants are products that are genetically incorporated into plant tissues including chemicals, proteins or dsRNA for pest control or anti-microbial activity. Qu et al. (this issue) systematically introduced bioinsecticides for pest control and discussed current constraints that prevent bioinsecticides from being widely used and proposed the future research directions in this issue (https://doi.org/10.15302/J-FASE-2021404). Xu et al. (this issue) optimized synthesis process of an anti-plant-virus candidate drug NK0238, and evaluated the antivirus activity and environmental safety of this product (https://doi.org/10.15302/J-FASE-2021390). Zhu et al. (this issue) investigated a new family of natural cyclic lipodepsipeptides with potent activity against Gram-positive bacteria. By genetic manipulation of accessory genes in the WAP biosynthetic gene cluster, new WAP-8294As were produced in Lysobacter, which confirmed the possibility to expand the spectrum of the biocontrol compounds (https://doi.org/10.15302/J-FASE-2021410). In addition, structural biology studies on action targets provides important insights on molecular functions. Using a structure-based drug design strategy, Zheng et al. (this issue) prepared a battery of novel triketone-quinoxaline compounds, which could be potentially applied to design new herbicides targeting p-hydroxyphenylpyruvate dioxygenase (https://doi.org/10.15302/J-FASE-2021401).

With the development and application of new biotechnology in agriculture, opportunities for crop protection are great becoming more abundant, opening new approaches, such as genetic engineering, to improve the plant resistance against crop pests and diseases. It is now feasible to control pests by directly targeting genes that are essential for the development and survival of insects and pathogenic microorganisms, for example, the sterile insect technique based on gene-drive and RNA interference using dsRNA. In addition, it has been confirmed that some gene families are effective targets that indirectly contribute to crop pests and diseases protection by targeting the plant biochemical synthesis or virus transmitting pathways. In this case, identifying new genes associated with the interaction between crops, insects, microorganisms should be a key focus, both now and in the future. Huang et al. (this issue) summarized the recent research on the interaction between plant viruses and insect vectors, and discussed the potential control strategies to prevent the transmission of insect-vectored plant viruses using RNAi technology, gene editing technology and gene-driven technology (https://doi.org/10.15302/J-FASE-2021389).

We anticipate that the ideas and approaches highlighted in this issue will help broaden reader’s perspectives on every increasing prospect for a new era of sustainable and environment-friendly agricultural pest management.

Wheat research and breeding in the new era of a high-quality reference genome

Rudi APPELS

《农业科学与工程前沿(英文)》 2019年 第6卷 第3期   页码 225-232 doi: 10.15302/J-FASE-2019265

摘要:

The publications of the International Wheat Genome Sequencing Consortium (IWGSC) released in August 2018 are reviewed and placed into the context of developments arising from the availability of the high-quality wheat genome assembly.

关键词: assembly technology     molecular markers     polyploidy     transcript networks     wheat genome    

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1407-5

摘要:

• Implication of COVID-19 on medical waste and MSW generation is studied.

关键词: COVID-19     Medical waste     Personal protective equipment     Municipal solid waste     Waste management    

Platform governance in the era of AI and the digital economy

《工程管理前沿(英文)》 2023年 第10卷 第1期   页码 177-182 doi: 10.1007/s42524-022-0241-1

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How do digital technologies improve supply chain resilience in the COVID-19 pandemic?

《工程管理前沿(英文)》   页码 39-50 doi: 10.1007/s42524-022-0230-4

摘要: Digital technologies (DTs) can assist businesses in coping with supply chain (SC) disruptions caused by unpredictability, such as pandemics. However, the current knowledge of the relationship between DTs and supply chain resilience (SCR) is insufficient. This study draws on information processing theory to develop a serial mediation model to address this deficiency. We analyze a sample set consisting of 264 Chinese manufacturers. The empirical results reveal that digital supply chain platforms (DSCPs), as well as supply chain traceability (SCT) and supply chain agility (SCA), fully mediate the favorable association between DTs and SCR. Specifically, the four significant indirect paths indicated that firms can improve SCR only if they use DTs to directly or indirectly improve SCT and SCA (through DSCPs). Our study contributes to the literature on resilience by examining the possible mechanism of mediation through which DTs influence SCR. The findings also offer essential insights for firms to modify their digital strategies and thrive in a turbulent environment.

关键词: digital technologies     supply chain resilience     information processing theory     COVID-19     China    

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

null

《医学前沿(英文)》 2016年 第10卷 第4期   页码 437-443 doi: 10.1007/s11684-016-0472-9

摘要:

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.

关键词: JAK     ruxolitinib     Chinese patients     myelofibrosis    

Managing supply chain resilience in the era of VUCA

Ying GAO , Zhuo FENG , Shuibo ZHANG

《工程管理前沿(英文)》 2021年 第8卷 第3期   页码 465-470 doi: 10.1007/s42524-021-0164-2

受疫情影响的半导体供应链危机

Mitch Leslie

《工程(英文)》 2022年 第9卷 第2期   页码 10-12 doi: 10.1016/j.eng.2021.12.006

Holistic integrative medicine: toward a new era of medical advancement

null

《医学前沿(英文)》 2017年 第11卷 第1期   页码 152-159 doi: 10.1007/s11684-017-0499-6

摘要:

Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine (HIM), which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.

关键词: holistic integrative medicine     precision medicine     general practice     medicine    

Dynamic modelling and simulation of a post-combustion CO capture process for coal-fired power plants

《化学科学与工程前沿(英文)》 2022年 第16卷 第2期   页码 198-209 doi: 10.1007/s11705-021-2057-7

摘要: Solvent-based post-combustion capture technologies have great potential for CO2 mitigation in traditional coal-fired power plants. Modelling and simulation provide a low-cost opportunity to evaluate performances and guide flexible operation. Composed by a series of partial differential equations, first-principle post-combustion capture models are computationally expensive, which limits their use in real time process simulation and control. In this study, we propose a first-principle approach to develop the basic structure of a reduced-order model and then the dominant factor is used to fit properties and simplify the chemical and physical process, based on which a universal and hybrid post-combustion capture model is established. Model output at steady state and trend at dynamic state are validated using experimental data obtained from the literature. Then, impacts of liquid-to-gas ratio, reboiler power, desorber pressure, tower height and their combination on the absorption and desorption effects are analyzed. Results indicate that tower height should be designed in conjunction with the flue gas flow, and the gas-liquid ratio can be optimized to reduce the reboiler power under a certain capture target.

关键词: CO2 capture     post-combustion capture     simulation     dominant factor    

标题 作者 时间 类型 操作

Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemicera

期刊论文

Special issue: Advancing supply chain resilience for excellence in the post-pandemic era

期刊论文

Digital twin for healthy indoor environment: A vision for the post-pandemic era

期刊论文

Advancing food supply chain resilience in the post-pandemic era

期刊论文

关于后摩尔时代我国集成电路制造领域的一些思考

吴汉明, 郑飞君

期刊论文

CROP PROTECTION OPENS UP NEW ERA OF CONSERVATION AND UTILIZATION OF GREEN OPTIONS

期刊论文

Wheat research and breeding in the new era of a high-quality reference genome

Rudi APPELS

期刊论文

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

期刊论文

Platform governance in the era of AI and the digital economy

期刊论文

How do digital technologies improve supply chain resilience in the COVID-19 pandemic?

期刊论文

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

null

期刊论文

Managing supply chain resilience in the era of VUCA

Ying GAO , Zhuo FENG , Shuibo ZHANG

期刊论文

受疫情影响的半导体供应链危机

Mitch Leslie

期刊论文

Holistic integrative medicine: toward a new era of medical advancement

null

期刊论文

Dynamic modelling and simulation of a post-combustion CO capture process for coal-fired power plants

期刊论文